Kinetics of Serum Cytokine Profile in Mice after Injection of Supernatants of Group A Streptococci Culture.

We analyzed cytokine profile in the sera of CBA mice in 1, 5, and 24 h after intraperitoneal injection of supernatants of broth cultures of group A Streptococcus types 1M and 3M and Dochez NY5 type 10M strain. The increase of the cytokine content was observed in response to supernatants of all three types, but the highest values were recorded after injection of supernatant of strain Dochez-NY5. The level of IL-2 increased most drastically (by 51 times) and the level of IL-5 increased by 8.9 times in comparison with the control. The level of IL-2 also increased after injection of supernatants of type 1M and type 3M, but to a lesser extent (by 5 and 2.3 times, respectively). The content of proinflammatory cytokines IL-1ß, TNFα, and IFNγ in mouse sera increased to a lesser extent than IL-2 after administration of all three supernatants.

[The evaluation of the clinical efficacy of complex treatment and preventive orthodontic and rehabilitation measures in children with spastic cerebral paralysis]. / Effektivnost' primeneniya kompleksa lechebno-profilakticheskikh ortodonticheskikh i reabilitatsionnykh meropriyatii u detei so spasticheskimi formami tserebral'nogo paralicha.

Based on the results of the comprehensive examination of 120 patients, the necessity of development and introduction of rehabilitation complex of therapeutic and preventive measures with regard to the type and severity of cerebral paralysis and patient's age in practice was shown. The main purpose of treatment and preventive measures was a complete social adaptation of children with spastic forms of cerebral paralysis, which was dependent on the integrity of speech functions. Rehabilitation measures were implemented by single multidisciplinary team with clear functional responsibilities of each member. The study determined the efficacy of treatment, preventive and rehabilitation measures in children with spastic forms of cerebral paralysis. It has been shown that the complex of treatment-and-preventive and rehabilitation measures for children with spastic forms of cerebral paralysis is positive and should be carried out continuously, from the early age to the maximum achievable level of correction of lost functions.